Diplomatic relations between the Philippines and Laos were established in 1955, shortly after the latter's independence from France on 19 July 1949. The Philippine Government conducted diplomatic relations with the Government of Laos through alternately, the Embassies in then Saigon, Vietnam and in Bangkok, Thailand.

The first Philippine Resident Ambassador to the Lao PDR was H.E. Felipe M. Mabilangan, Sr., who presented his credentials to the King of Laos on 26 October 1965. Ambassador Trinidad Legarda, who was based in Saigon succeeded him. From 1970 to 1974, the Embassy was headed by a Chargé d’affaires, until the assignment of Ambassador Jose M. Evangelista in August 1974. The Embassy was closed in 1980 and until its reopening in 1998, relations were conducted through the Philippine Embassy in Bangkok, with the Philippine Ambassador accredited as Non-Resident Ambassador to the Lao PDR.

With Lao PDR’s admission to the Association of Southeast Asian Nations (ASEAN) in 1997, a resident embassy was reopened in July 1997. Following are the Ambassadors from 1997 to present:

- H.E. Jaime J. Yambao, 1997 to 2001 

- H.E. Mario I. Galman, 2001 to 2003

- H.E. Antonio Cabangon Chua, 2003 to 2004

- H.E. Elizabeth P. Buensuceso, 2004 to 2008 (initially as Chargé d’affaires, a.i. then as Ambassador Extraordinary and Plenipotentiary in May 2005)

- H.E. Marilyn J. Alarilla, 2008 to 2012

- H.E. Maria Lumen B. Isleta, 2012 to 2015

- H.E. Belinda M. Ante, 2016 to 2021

- H.E. Deena Joy D. Amatong, 2021 to present

 CONCLUDED BILATERAL AGREEMENTS 

1. MOU on Trade and Investment Cooperation (1994)
2. Agreement on Agricultural and Forestry Cooperation (1997)
3. Agreement on Economic and Technical Cooperation (1998)
4. Agreement on Public Health Cooperation (1997)
5. Memorandum of Agreement on Cooperation Against Illicit Trafficking of Narcotic Drugs and Psychotropic Substances and Abuses thereof (1997)
6. Agreement on Cultural Cooperation (1998)
7. Agreement on the Exemption from Visas for Holders of Ordinary Passports (2005)
8. MOU on Technical Cooperation on Labour and Employment (2005)
9. MOU for Technical Cooperation in the fields of Electric Plant Engineering, Operations and Maintenance Services and Rural Electrification (2006)
10. MOU on the Documentary Film Production on the 450th Founding Anniversary of the City of Vientiane signed by the Laos Ministry of Information and Culture, the DFA and the Academe-Civil Society Network of Southeast Asia (2010)
11.  MOU between the PH Foreign Service Institute (FSI)and the Lao Institute of Foreign Affairs (IFA) (signed during Lao PM’s visit, 10 May 2012)
12. MOU between the Philippine Sports Commission (PSC) and the Lao Ministry of Education and Sports on Sports Cooperation (signed during Lao PM’s visit, 10 May 2012)
13. MOU between the University of the Philippines-Los Baños and the National University of Laos (signed during Lao PM’s visit, 10 May 2012) (academic institutions)
14. Cooperation Agreement between the Philippine Chamber of Commerce and Industry and the Lao National Chamber of Commerce and Industry (signed during Lao PM’s visit, 10 May 2012) (private sector – signed by PCCI President Miguel Varela and LNCCI President Kissana Vongxay; and the Business Council Chairs of the Philippines and Laos)